Resident Evil: Degeneration, known in Japan as Biohazard: Degeneration (バイオハザード：ディジェネレーション Baiohazādo: Dijenerēshon), is the first full-length CG animation feature based upon Capcom's Resident Evil video game series. The film was made by Capcom Studios in cooperation with Sony Pictures Animation and Sony Pictures Entertainment. Degeneration made its premiere in Japan on October 11, 2008 at the Tokyo Game Show, and was released nationwide one week later on October 18.

Unlike the Resident Evil live-action film series, Degeneration is set within the same universe as the original video game series. The main characters are Leon S. Kennedy and Claire Redfield, who appear together for the first time since the 1998 game Resident Evil 2.