Johnny Depp:

Sleepy Hollow: 30 million (November 1999)
From Hell: 11 million (October 2001)
Pirates of the Caribbean: The Curse of the Black Pearl: 46 million (three-day) [July 2003]
Once Upon a Time in Mexico: 23 million (September 2003)
Charlie and the Chocolate Factory: 56 million (July 2005)
Pirates of the Caribbean: Dead Man's Chest: 135 million (July 2006)
Pirates of the Caribbean: At World's End: 114 million (three-day) [May 2007]
Alice in Wonderland: 116 million (March 2010)
Rango: 38 million (March 2011)
Pirates of the Caribbean: On Stranger Tides: 90 million (May 2011)

10 since 1999.

This is way too sausage fest-y. Time for a female actor!

Julia Roberts

Pretty Woman - 11.3 million (March 1990)
Flatliners - 10 million (August 1990)
Sleeping With The Enemy - 13.7 million (February 1991)
Hook - 13.5 million (December 1991)
The Pelican Brief - 16.8 million (December 1992)
Conspiracy Theory - 19.3 million (August 1997)
Runaway Bride - 35 million (July 1999)
Erin Brockovich - 28 million (March 2000)
The Mexican - 20.1 million (March 2001)
Ocean's Eleven - 38.1 million (December 2001)
Ocean's Twelve - 39.1 million (December 2004)
Valentine's Day - 56.2 million (February 2010)

12 since 1990.

Eddie Murphy probably has more than 10, anyone care to make a list?

I'll get right on it. Oh wait

That's only 8???

LOL. I forgot there was a list already.

Harrison Ford

Star Wars- 1.5 million (77) Actually opened in first in limited, and again in wide
Heroes- 1.1 million (77)
The Empire Strikes Back- 4.9 million (80)
Raiders of the Lost Ark- 8.3 million (81)
Return of the Jedi- 23 million (83)
Indiana Jones and the Temple of Doom- 25.3 million (84)
Indiana Jones and the Last Crusade- 29.4 million (89)
Presumed Innocent- 11.7 million (90)
Patriot Games- 18.5 million (92)
The Fugitive- 23.4 million (93)
Clear and Present Danger- 20.3 million (94)
Air Force One- 37.1 million (97)
What Lies Beneath- 29.7 million (00)
Indiana Jones and the Kingdom of the Crystal Skull-100 million (08)
Cowboys & Aliens- 36.4 million (11)
42- 27.5 million (13)
Ender's Game- 27 million (13)

Total- 17 from 1977-2013
Highest- Indiana Jones and the Kingdom of the Crystal Skull- 100.1 million
Top 3 Adjusted- IJ (113 million) Air Force One (65 million) IJ TOD (60 million)
Note- Obviously Return of the Jedi is the most impressive opening of all time. Not sure if American Graffiti opened to #1

.. Yes.

Yes. I counted 21 movies.

Robbie Coltrane has 15 or 16. BOW DOWN TO THE COLTRANE.

Is it really fair to include actors who only played supporting roles in #1 openers? Even if we don't just count films in which the actor/actress starred (in which case Stallone would only have 15 - he was only a supporting role in Antz and Spy Kids 3, and an uncredited cameo in Staying Alive), we should at least stick to legitimate "stars."

Anyway, time for another female:

Sandra Bullock

Demolition Man - $14.3M (1993)
Speed - $14.5M (1994)
While You Were Sleeping - $9.3M (1995)
A Time to Kill - $14.8M (1996)
Speed 2 - $16.2M (1997)
Practical Magic - $13.1M (1998)
Forces of Nature - $13.5M (1999)
The Proposal - $33.6M (2009)
Gravity - $55.8M (2013)

Total - 9 from 1993-2013
Highest - Gravity - $55.8M
Top 3 Adjusted* - Gravity (55.8), The Proposal (36.3), Speed 2 (28.3)
*#1 openers only - Bullock's overall top 5 adjusted openings are Gravity, The Heat (non-#1), The Proposal, The Blind Side (non-#1) and Speed 2

Gravity is the biggest, both unadjusted and adjusted. Interesting to see that Bullock went 10 years without a #1 opener, while her three biggest hits from that decade (Miss Congeniality, Divine Secrets of the Ya-Ya Sisterhood, and Two Weeks Notice) had much better overall runs than her three previous #1 openers (which have the lowest adjusted totals of any of her #1 starts).

In fact, out of Bullock's current adjusted top 10, 4 of them (5 if you include The Prince of Egypt) opened at #2 or lower - including her top film, The Blind Side. And before The Proposal, 5 of her adjusted top 10 (6 if you count Prince of Egypt again) weren't #1 openers. Before 2009, Bullock wasn't in a single film whose opening adjusts to $30m or more. So Bullock's films have always been more about legs than openings. (Miss Congeniality had a 10.6x multiplier - it only opened at #5!)

Tom Hanks

Splash- 6.2 million (84)
Dragnet- 10.5 million (87)
The Burbs- 11.1 million (89)
Turner and Hooch- 12.2 million (89)
Philadelphia- 13.8 million (93)
Forrest Gump- 24.4 million (94)
Apollo 13- 25.4 million (95)
Toy Story- 29 million (95)
Saving Private Ryan- 30.6 million (98)
You've Got Mail- 18.4 million (98)
Toy Story 2- 57.4 million (99)
Cast Away- 28.9 million (00)
The Da Vinci Code- 77 million (06)
Angels and Demons- 46.2 million (09)
Toy Story 3- 110.3 million (10)

Total- 15 from 1984-2010
Highest- Toy Story 3- 110.3 million
Top 3 Adjusted- Toy Story 3 (112) Da Vinci Code (94) Toy Story 2 (91)

Jeff Bridges:

King Kong: 7 million (December 1976)
The Fisher King: 7 million (expansion in September 1991)
K-PAX: 17 million (October 2001)
Iron Man: 98 million (May 2008)
Tron: Legacy: 44 million (December 2010)

5 since 1976. True Grit did not open at number one, but reached the top later in its run.

Tom Cruise:

Legend- 4.3 million (86)
Top Gun- 8.2 million (86)
Cocktail- 11.8 million (88)
Born on the Fourth of July- 11 million (89)
Days of Thunder- 15.5 million (90)
A few Good Men- 15.5 million (92)
The Firm- 25.4 million (93)
Interview with The Vampire- 36.4 million (94)
Mission Impossible- 45.4 million (96)
Jerry Maguire- 17 million (96)
Eyes Wide Shut- 21.7 million (99)
Mission Impossible II- 57.8 million (00)
Vanilla Sky- 25 million (01)
Minority Report- 35.7 million (02)
The Last Samurai- 24.3 million (03)
Collateral- 24.7 million (04)
War of the Worlds- 64.9 million (05)
Mission Impossible III- 47.7 million (06)
Tropic Thunder- 25.8 million (08)
Mission Impossible: Ghost Protocol- 29.6 million (11)
Oblivion- 37 million (13)

Total: 21 from 1986-2013
Highest opening: War of the Worlds- 64.9 million
Top 3 Adjusted: MI2 (86) Mission Impossible (82) War of the Worlds (81.5)
[b]Note: I put MI4 in there because, it did open to #1 4 days after it's limited release, and it obviously would have went #1 no matter what/b]

I'm sure a few more of his from the 70s hit number 1 too. I'm sure Thunderbolt and Lightfoot did. Eastwood would probably win this, but, he's without so much info.

I am sure Redford's count would be much higher, too, if there was information from the 1970s.

Another one for the ladies:

Nicole Kidman

Days of Thunder - $15.5M (1990)
Malice - $9.2M (1993)
Batman Forever - $52.8M (1995)
The Peacemaker - $12.3M (1997)
Practical Magic - $13.1M (1998)
Eyes Wide Shut - $21.7M (1999)
The Interpreter - $22.8M (2005)
Happy Feet - $41.5M (2006) [Should this count? She wasn't in a starring role]
The Golden Compass - $25.8M (2007)
Just Go With It - $30.5M (2011)

Total - 10 from 1990-2011 (9 if you don't count Happy Feet)
Highest - Batman Forever - $52.8M
Top 3 Adjusted - Batman Forever (97.7), Happy Feet (51.0), Just Go With It (31.3) [and if not counting Happy Feet: The Golden Compass (30.2)]

Another actress:

Cameron Diaz

The Mask - $23.1M (1994)
Any Given Sunday - $13.6M (1999)
Charlie's Angels - $40.1M (2000)
Shrek - $42.3M (2001)
Vanilla Sky - $25.0M (2001)
Charlie's Angels: Full Throttle - $37.6M (2003)
Shrek 2 - $108.0M (2004)
Shrek the Third - $121.6M (2007)
Shrek Forever After - $70.8M (2010)
The Green Hornet - $33.5M (2011)

Total - 10 from 1994-2011
Highest - Shrek the Third - $121.6M
Top 3 Adjusted - Shrek the Third (142.3), Shrek 2 (140.0), Shrek Forever After (72.4)

Will Smith has 12 #1 openings

John Travolta

Staying Alive- $12.1M (1983)
Look Who's Talking- $12.1M (1989)
Pulp Fiction- $9.3M (1994)
Get Shorty- $12.7M (1995)
Broken Arrow- $15.6M (1996)
Michael- $14.4M (1996)
Face/Off- $23.4M (1997)
Swordfish- $18.1M (2001)
Wild Hogs- $39.7M (2007)

TOTAL: 9 (1983- 2007)
Top Opening: Wild Hogs- $39.7M
Top 3 Adjusted: Wild Hogs- $46.5M, Face/Off- $41M, Michael- $31.8M

Sigourney Weaver

Alien- $3.5M (1979)
Deal of the Century- $3.5M (1983)
Ghostbusters- $13.6M (1984)
Aliens- $10.1M (1986)
Ghostbusters II- $29.5M (1989)
Heartbreakers- $11.8M (2001)
The Village- $50.7M (2004)
Vantage Point- $22.9M (2008)
Baby Mama- $17.4M (2008)
WALL-E- $63.1M (2008)
Avatar- $77M (2009)

TOTAL: 11 (1979-2009)
Top Opening: Avatar- $77M (2009)
Top 3 Adjusted: Avatar- $81.5M, WALL-E- $70.7M, The Village- $65.8M

Travolta should be 11, not 9. Both Saturday Night Fever and Grease opened at #1.

Do we or don't we count cameos/supporting roles? If WALL-E counts for Sigourney Weaver, maybe Stallone should be bumped back up to 17?

There definitely seems to be a "glass ceiling" for actresses consistently in #1 openers. None above Julia Roberts' 12.

Actually SMOKEY AND THE BANDIT was No. 1 when STAR WARS opened Memorial Day weekend...

Owen Wilson

The Cable Guy- $19.8M (1996) [CAMEO]
Anaconda- $16.6M (1997)
Armageddon- $36.1M (1998) [CAMEO]
The Haunting- $33.4M (1999)
Meet the Parents- $28.6M (2000) [CAMEO]
Meet the Fockers- $46.1M (2004) [CAMEO]
Cars- $60.1M (2006)
Night at the Museum- $30.4M (2006)
Marley and Me- $36.4M (2008)
Night at the Museum: Battle of the Smithsonian- $54.2M (2009)
Little Fockers- $30.8M (2010)
Cars 2- $66.1M (2011)
Hall Pass- $13.5M (2011)

TOTAL: 13
TOTAL W/O Cameos: 9
Top Opening: Cars 2- $66.1M
Top 3 Adjusted: Cars- $73.9M, Cars 2- $66.1M, Armageddon- $61.9M

Samuel L. Jackson
Loaded Weapon 1 - $9.2M (1993)
Pulp Fiction - $9.3M (1994)
Die Hard: With a Vengeance - $22.2M (1995)
A Time to Kill - $14.8M (1996)
Rules of Engagement - $15.0M (2000)
Shaft - $21.7M (2000)
Changing Lanes - $17.1M (2002)
XXX - $44.5M (2002)
S.W.A.T. - $37.1 (2003)
The Incredibles - $70.5M (2004)
Coach Carter - $24.2M (2005)
Snakes on a Plane - $13.8M (2006)
1408 - $20.6M (2007)
Jumper - $27.3M (2008)
Lakeview Terrace - $15.0M (2008)

Bit Parts:
Jurassic Park - $47.0M (1993)
Star Wars: Episode I - The Phantom Menace - $64.8M (1999)
Star Wars: Episode II - Attack of the Clones - $80.0M (2002)
Kill Bill Vol. 2 - $25.1M (2004)
Star Wars: Episode III - Revenge of the Sith - $108.4M (2005)
Iron Man - $98.6M (2008)
Iron Man 2 - $128.1M (2010)
The Other Guys - $35.5M (2010)
Marvel's The Avengers - $207.4M (2012)

TOTAL: 15 (1993-2008)
Total Including Cameos: 24
Top Opening: The Incredibles - $70.5M (2004)
Top 3 Adjusted: The Incredibles - $91.3M (2004), XXX - $61.7M (2002), S.W.A.T. - $49.5M (2003)