A young fashion designer seems fine on the surface but secretly struggles with debilitating self-doubt. Soon these buried feelings begin to make Hannah physically sick and sprout into a ferocious growth on her body: The Appendage. As Hannah's health declines, The Appendage grows more powerful and begins to fuel her anxieties - her perceived lack of talent at work, her deteriorating relationships with her boyfriend and best friend and her parents' lack of love and understanding. At her breaking point, Hannah makes a shocking discovery - there are others out there like her.