Play It to the Bone is a 1999 sports/comedy-drama film, starring Antonio Banderas and Woody Harrelson, written and directed by Ron Shelton.

It follows the adventures of two boxers and best friends who travel to Las Vegas in order to fight each other for the sake of a chance to compete for the middleweight title. The film also starred Lolita Davidovich, Tom Sizemore, Lucy Liu, and Robert Wagner.

Cameo appearances include: Steve Lawrence, Tony Curtis, Wesley Snipes, Mike Tyson, Kevin Costner, Rod Stewart, Jennifer Tilly, Natasha Gregson Wagner, Drew Carey and Chuck Bodak. The film was released to neither critical acclaim nor commercial success.