Stuart Little is a 1999 family film. It is loosely based on the novel of the same name by E. B. White. It combines live-action and computer animation. The screenplay was co-written by M. Night Shyamalan and Greg Brooker, with uncredited script doctoring by David O. Russell and Billy Ray. The plot of the film bears little resemblance to that of the book; only some of the characters and one or two minor plot elements are the same. The film's sequel more closely resembles the original novel.

Michael J. Fox is the voice of Stuart Little. Geena Davis and Hugh Laurie star as Eleanor and Frederick Little, with Jonathan Lipnicki as Stuart's big brother George Little and Nathan Lane as the voice of the family cat Snowbell.

The film was released on December 17, 1999 by Columbia Pictures.

It received an Academy Award nomination for Best Visual Effects. The film spawned a sequel in 2002, Stuart Little 2.